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"Authorities Misinterpreting COVID-19 Trial Data 'Disastrous'" Topic


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wmyers09 Sep 2020 6:34 p.m. PST

Authorities misinterpreting COVID-19 trial data with 'disastrous' results, Canadian researchers say.

Influenced by media accounts, scientific oversight boards often don't recognize there are distinct phases to COVID-19 sickness.

When British scientists studying potential treatments for COVID-19 released early results on hydroxychloroquine in June, it was not good news.

For patients sick enough with the coronavirus to be hospitalized, there was no evidence the controversial malaria drug did them any good. The RECOVERY trial found the same for the HIV therapy lopinavir.

The findings had a dramatic effect. Around the world ethics boards and funding bodies ended "dozens if not hundreds" of studies on hydroxychloroquine and lopanivir, says Edward Mills, a Canadian clinical trials expert.

The problem with that, he says, is that many of those other trials were looking at the medicines as a treatment for outpatients in a milder phase of the disease, or as a "prophylaxis" to prevent infection in the first place.

The impact on severely ill patients what the widely respected U.K. trial examined was largely irrelevant to their work, says Mills, a McMaster University professor who advises the Gates Foundation on clinical trials.

The episode was typical of what has become a serious problem in the COVID-19 pandemic: misinterpretation of trial data, with "disastrous" results for other studies, Mills and colleagues argue in a recent medical journal commentary ( link ).

Sir Nick White, an Oxford University tropical-medicine professor, confirmed by email that his own planned study of hydroxychloroquine as a preventive was ordered shut down because of the RECOVERY results. ( link )

Prematurely ending trials because of misinterpretation and other factors means it's still unknown whether drugs like hydroxychloroquine could, in fact, be useful as preventives or early in the illness, Mills said.

He traces the problem in part to the unprecedented way science is being communicated during the pandemic.

link

wmyers16 Sep 2020 10:01 p.m. PST

Nevada is now the 7th state to quietly reverse their decision to block HCQ prescriptions for COVID-19. Physicians in Nevada can now once again prescribe HCQ as they deem necessary.

link

link

MiniPigs17 Sep 2020 6:18 a.m. PST

What a bizarre way to interpret an expiring temporary regulation against stockpiling that declared itself to be such.


I think I prefer to go with a professional that can interpret data with a more precise clairvoyance:

link

link

wmyers17 Sep 2020 3:49 p.m. PST

May?

MiniPigs17 Sep 2020 6:14 p.m. PST

Whats the difference? Do you think the medical trials change in a month?

Here's July. Do we need daily updates from him on that drug?


link

I prefer his opinion rather than Dr nobody from nowhere tweeting that standard, every day legal behavior jives with the conspiracy she is trying to push.

Whats next, when red traffic lights turn green, it's the city admitting you really dont have to stop in your car?

Oh dear, she's an anti mask ranter. What a shock:

link

wmyers18 Sep 2020 6:30 a.m. PST

The original post contradicts your claims.

MiniPigs19 Sep 2020 6:25 a.m. PST

Im not making any claims.

I went over the link in your first post it also concludes that Hydroxi-blah-blah-blah is useless for Covid-19. Im not reading that other linked piece in the first post.

Deleted by Moderator

wmyers19 Sep 2020 9:58 a.m. PST

Then you must not have read it properly.

It states HCQ trials have been cancelled because of improper usage of the drug in treatment. Late treatment with it does not work but early treatment is another set of findings.

Sir Nick White, an Oxford University tropical-medicine professor, confirmed by email that his own planned study of hydroxychloroquine as a preventive was ordered shut down because of the RECOVERY results. ( link )

Prematurely ending trials because of misinterpretation and other factors means it's still unknown whether drugs like hydroxychloroquine could, in fact, be useful as preventives or early in the illness, Mills said.

The paper goes on to state it is assumptions like that which are the problem.

He traces the problem in part to the unprecedented way science is being communicated during the pandemic.

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