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"Antibiotic resistance " Topic


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275 hits since 30 Jun 2016
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Personal logo Bowman Supporting Member of TMP01 Jul 2016 7:40 a.m. PST

….All the key players are now in place to make the post-antibiotic world a reality.

bbc.com/news/health-34857015

One bright spot:

link

link

It seems human clinical trials are slated for 2017. One problem right off the bat is that teixobactin seems to only affect gram negative bugs. But the I-chip may discover more Bacteria created antibiotics.

Terrement Supporting Member of TMP01 Jul 2016 8:04 a.m. PST

Have to wonder if it isn't a never-ending tail-chase.

Winston Smith Supporting Member of TMP01 Jul 2016 8:08 a.m. PST

It's evolution at play. The bugs who aren't killed by the current antibiotics survive. On 100 years, penicillin will be potent again.

Personal logo Bowman Supporting Member of TMP01 Jul 2016 11:22 a.m. PST

It's not even that long. Old, seemingly innocuous antibiotics such as Erythromycin become somewhat useful again. That took, what, 30 or so years?

It's analogous to ancient farmers leaving some of their fields fallow to increase production in the fields being farmed. They would rotate the fallow fields. So just like crop rotation, perhaps a regimen is developed to allow antibiotic rotation. The problem is that (here the analogy breaks down) it doesn't mean that the gene that cleaves amoxicillin is necessarily lost, just because we stopped amoxicillin use for a few decades. That means that there is no guarantee that returned antibiotics will resume their previous potency.

It is evolution at play, but at a horrendously accelerated rate of development. Prokaryotes and eukaryotes developed chemical means to kill bacteria perhaps as long as a billion years ago for eukaryotes to even longer for bacteria killing competing bacteria.

We isolated the first antibiotic less than 90 years ago and have discovered or modified many others. Up until teixobactin was discovered the last class of antibiotic was developed in 1987. Evolution is at play and can play us out of existence. This is something we will have to solve.

Terrement Supporting Member of TMP01 Jul 2016 1:58 p.m. PST

Having to solve it and solving it are not necessarily the same thing.

Personal logo Bowman Supporting Member of TMP01 Jul 2016 7:34 p.m. PST

No, it isn't

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