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One of the greatest misunderstandings about transhumanism is that it is merely high-tech, technophilia, genetic engineering, bionics, cyberpunk, virtual reality, a technological Singularity, or a combination thereof. It is not.
Simply put, transhumanism is the process of consciously improving oneself, or a group of people, beyond the limitations of "baseline" humanity, and thereby create a new, post-human species. Without that conscious desire to exceed humanity, one is neither a transhumanist nor a transhuman. One can be a technophile, or a cyborg, or genetically enhanced, but unless that is coupled with the goal of moving beyond "humanity", it is not transhumanism. There is a reason that a common transhumanist symbol in the early days was >H.
Now, transhumanism certainly can involve all those things I mentioned above. Space exploration, nanotechnology and post-scarcity economies, cybernetics, virtual realities, cryonics, artificial intelligence; all these things and more are staples of transhumanist interests and projections. But they do not, in and of themselves, make something transhumanist. For that, one must have the desire to create (or become) a new, post-human species.
In game terms, as well as in fiction, the ripest field for exploring this theme is the conflict between baseline humans and the transhumans (and/or posthumans). Conflicts between different transhuman factions are also possible, maybe based on their attitudes towards the baseline humans. (And yes, there are definitely "factions" among contemporary transhumanists along such lines, as well as how transhumanist-potential technologies should be distributed or made accessible.)
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Are you one of them?
Amicalement
Armand