"Mutations generate genetic variation, and are a major driving force of evolution. Therefore, examining mutation rates and modes are essential to better understand the genetic basis for physiology and evolution.
One traditional method to estimate this rate is a 'phylogenetic' approach that examines the sequence divergence between two species, and the time between divergence events. However, this method entails many uncertainties, such as the extent of ancestral polymorphisms, effective population size, and generation time.
To overcome these difficulties and estimate mutation rates directly, a team of researchers including Tetsuro Matsuzawa of the Kyoto University Institute for Advanced Study (KUIAS) and Yasuhiro Go of Japan's National Institutes of Natural Sciences (NINS) conducted a study utilizing high-quality whole genome sequencing of a chimpanzee parent-offspring trio, and successfully disclosed the precise mutation rates and modes through the transmission of genomes from parents to child.
It is well known that chimpanzees are humans' closest genetic relatives. The trio of Akira, Ai, and Ayumu (father, mother, son) in this study have taken part in a wide variety of comparative cognitive research -- notably in "The Ai-Project" led by Matsuzawa -- dating back to 1978.
Due to the abundance of this previous cognitive research, the authors anticipate that these chimpanzees can facilitate an understanding of how genetic architecture influences phenotypic -- cognitive -- traits, shedding light on the development of individuality…."
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