Rasillion covered things petty well.
Given your interests expressed on this group, I'd say look real hard at:
Experience Music Project and Science Fiction museum (Seattle Center/Space Needle/Pacific Science Center), all same location. This is a totally unique thing -- nothing else like it anywhere. Plan to spend at least a day -- maybe two.
and the Underground tour. A must for Fans of FRP
Pike Street is always fun but . . . as a tourist, not a major thing unless you are buying dinner to cook.
There is a Suites place way up Pike street (but still walking distance from the market) room rates are about the same as hotel rooms and you have a kitchen where you can cook the stuff you buy at Pike Street. I think this is a Hilton property right now but they sell the thing every year or so -- hard to keep up if you live outa town. Anyway that's where I always stay.
The Mariners stink this year but Safeco Stadium is relatively new and as nice a park as you would want to go to. Has a retractable roof. No problem getting really good seats this year . . . there is that I guess.
The Sea Hawks might still be doing preseason games. I find these prohibitively expensive (even the nose bleed section during pre-season) but you can get tickets to the pre-season games. Fans are rabid -- interesting experience if you are into that kind of thing.
The WNBA team in Seattle is pretty good if you like their league. Tickets are reasonable and they never sell out. Dunno if they will still be playing at that time or not.
Downtown Seattle is relatively safe. Seems like they frequently have 2-4 pan handlers on every corner but otherwise no reason you cannot walk around down there. I used to take my kids to the baseball games and we would walk back at night.
Seattle has a number of night clubs with live music. I don't drink and I like to hear myself think – so generally don't go out with the kids. The kids really like these venues now they have grown up.
In recent years the Space Needle restaurant has been hard to get into. Didn't used to be that way. If you want to eat dinner there (recommend a late dinner around sunset) you should probably make reservations in advance.
There are a number of theaters that are walking distance from the Suites place I mentioned (like less than 6 blocks). Productions are very good to great. My wife is the theater buff. Me?
If my wife has someone to go with, I'll go play games with Allan Dyer and his crew at least one night (Seattle Metro Gamers -- nice bunch of folks -- something going on down there almost every night -- very varied menu from historical miniatures to board games (be careful if the get out that power grid game -- you have no chance).
I dunno what you do professionally, but there are frequently continuing education meetings for just about every profession imaginable at the Convention Center (which is a block from the Suites place. I generally will pick up some CLE when I am in town.
The food in Seattle is highly variable in quality and price. Recent trips have revealed a general decline in quality and a significant increase in price.
That said the restaurant at Snoqualmie falls is to die for. Be prepared to pay through the nose for it.
The downtown hotel restaurants compete with each other and are often quite good if a little pricy.
There are some Chinese restaurants (in china town) that are actually quite good.
Never eat at sports bars or dance clubs -- you will regret it.
There is a guy that makes sausages outside of Safeco before the baseball games. You can take these into the park with you. Hands down the best baseball food you will find. Make sure you let him load it up with everything he offers. Costs a bit more but is an outstanding treat!