I'm going to make predictions (possible spoilers)
Arya finally goes after Cersei and discovers the fecal matter has hit the oscillating revolving air displacement device with a vengeance, and she needs dragonglass to finish the job.
Dany and her dragons die, leaving somebody else to plonk their butts on the metal contraption of power, if she doesn't have her dragon melt it symbolically. Jon is probably going to end up in a kind of Lord Protector or returns to the wall, when they figure the Others are tied to some eternal cycle or somesuch.
Cleganebowl, Mountain wipes the floor with his kid brother, cuts him into ribbons but he lives long enough to lob the big guy's head off and then bleeds out. Possibly as the climax of one last heroic deed, like opening the way for Arya to get at Cersei.
The initial plan is to stand at Winterfell, this fails the survivors have to try again in open battle and barely manage a win.
Maester Mengele looked all shook up from what Cersei is smirking at, this is the moment he realizes she's gone round the bend, he either is executed by her or sacrifices himself rather than let his latest discovery/invention get out of
hand.
Euron is going to be a big wrench in a lot of plans and probably survives just to be a thorn in the side of the survivors.
It's not going to be a happy season and knowing GRRM's preponderance for nasty twists, I can't see him do a traditional ending with Dany and Jon on the throne, dragons snoozing in the background and everything set right.
If anything it may on a precarious, slightly hopeful balance of power that might tilt again when the next Littlefinger comes along to give it a good kick.
